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Description

Across the entire orforglipron clinical development program, no hepatic safety signal has been identified

As the discontinuation rates were also high with the twice daily danuglipron at the phase 2 obesity trial (as discussed above), twice daily danuglirpon formulation will not advance into phase 3 studies, but an improved once-daily formulation with an aim to improve tolerability profile is currently under assessment [27]

Provided as lyophilized powder requiring reconstitution with bacteriostatic water

Cell 56, 10191032

Booth RG Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling