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The number and function of ECs decline with age, resulting in increased apoptosis of ECs in the muscle, diminished neovascularization, and loss of blood vessels (Wang et al., 2014)

Clin Neurosci Res 6:261281 Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL (2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

Suggested table of clinical case studies (to include in article): columns for patient phenotype (age, BMI, diagnosis), peptide used (dose, duration), metabolic outcomes (weight change, HOMA-IR), reproductive outcomes (ovulation, oocyte yield, pregnancy), adverse events, and follow-up duration, such as PCOS, obesity-associated anovulation, poor ovarian response, and metabolic syndrome

Furthermore, expanding NPPCs in vitro presents challenges in reliably maintaining their progenitor phenotype during culture

5 Additionally, patients often develop tolerance to analgesics, necessitating prolonged high-dose therapies and combination regimens