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Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane (51), is transported into the blood circulation through Ferroportin1 (FPN1) on the intestinal epithelial cell membrane, and is then converted to Fe 3+ by heparin (Hp) or ceruloplasmin (52)

Therefore, we speculate that the interstitial fibrosis observed in HUA mice is mainly correlated with noradrenaline associated vascular effect

Larsen AT, Melander SA, Sonne N, et al

Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H

doi: 10.1038/cddis.2016.63 109

J Ovarian Res (2015) 8:29