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This review comprehensively synthesizes current knowledge regarding the microbiotaferroptosis crosstalk in ALD, with particular emphasis on microbial regulation of hepatic iron homeostasis and microbiota-driven modulation of oxidative stress through lipid peroxidation and antioxidant system interactions

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For instance, administration of leptin into the brain ventromedial hypothalamus stimulated glucose uptake and oxidation in multiple tissues, including the heart, and this effect appeared to be independent of insulin since CNS leptin administration did not increase plasma insulin levels [22]

As such, increased levels of sdLDL have the potential to provide additional information regarding risk of CVE in individuals with normal LDL-C levels but elevated triglycerides and low HDL