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Week 1-4: 1mg weekly Week 5-8: 2mg weekly Week 9-12: 4mg weekly Week 13-16: 6mg weekly Week 17-20: 8mg weekly Week 21+: 12mg weekly (if tolerated) The Phase 3 TRIUMPH-4 trial used a slightly modified approach

Documented clinical safety signals across the peptide class include a halted clinical trial following a fatal cardiac event, case reports of melanoma and kidney dysfunction, and a documented death following intravenous administration

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Reducing adipose tissue lowers systemic estrogen, which can reduce stimulation of endometrial implants

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