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Several researchers have evaluated the potential of these phytocompounds (Table 3) and underlying anti ulcerative mechanisms using various animal models that have been summarized below: 6.4.1 Nitrogen containing compounds Nitrogen containing secondary metabolites, especially derived from medicinal plants exhibits a potent anti-inflammatory and immune regulating properties against UC [123]

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The Mediterranean diet, which includes abundant fruits, vegetables, olive oil and whole grains, is loaded with dietary fiber, polyphenols, and unsaturated fatty acids, which improve beneficial bacteria growth, such as butyrate producers, including Clostridium leptum and Eubacterium rectale , and reduce the growth of pro-inflammatory bacteria such as Firmicutes

Subsequently, his group kept on the modification of the substituent depended on this skeleton, and got a library of the thiazolidine-2,4-dione derivatives

27 Notably, polyphenols, a class of plant-based compounds found in foods like fruits, vegetables, spices, and tea, have garnered attention for their potent antioxidative properties