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4.2 mtDNA-induced inflammatory responses Akin to bacteria, mtDNA contains hypomethylated CpG motifs that are potent inducers of inflammation (Nakayama and Otsu, 2018)

130 (4), 1007S1015S

Epidemiology, risk factors, and lifestyle modifications for gout

doi: 10.3390/cells12222608 29

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J Immunol 189(6):26892695 Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daler-Plenker J, Guerci P, Huynh C, Knight JS (2020) Targeting potential drivers of COVID-19: neutrophil extracellular traps