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The findings further illustrate the diversified modes of metformin in NAFLD treatment with direct effects on the liver and indirect actions via extrahepatic pathways

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doi: 10.1073/pnas.1308535110 132

Examining the relationship between glutathione and post-traumatic headache in patients with persistent post-concussive symptoms Julie M Joyce 1,2,3,4 , Leah J Mercier 2,4,5 , Parker L La 1,2,3,4 , Tiffany Bell 1,2,3 , Julia M Batycky 2,4,5 , Chantel T Debert 2,3,4,5 , and Ashley D Harris 1,2,3,4 1 Department of Radiology, University of Calgary, Calgary, AB, Canada, 2 Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4 Integrated Concussion Research Program, University of Calgary, Calgary, AB, Canada, 5 Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Using edited spectroscopy, we found increased glutathione in the anterior cingulate is associated with greater functional impact of headache in patients with persistent post-concussive symptoms suggesting oxidative stress is related to post-traumatic headache