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4,16,17,18,19,20,21,22 Increased HIF activity in tubular epithelial cells prior to the onset of a toxic or ischemic renal insult appears to diminish the severity of tubular injury, which should be a beneficial effect, but increased expression of HIF in tubular epithelial cells has also been shown to trigger interstitial fibrosis, which is linked to loss of kidney function

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10.1053/j.gastro.2013.05.018 23