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Sharma S, Dominguez AL, Lustgarten J

It is noteworthy that the gut microbiota functions as a central mediator in the bidirectional communication between the GI system and the brain, a network commonly known as the microbiotagutbrain axis (9)

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The liver responds to GH by producing IGF-1 , and IGF-1 is what actually drives the downstream tissue effects clinicians associate with growth hormone protein synthesis, satellite-cell activation for muscle repair, lipolysis, collagen synthesis, and bone remodeling