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The inclusion criteria were i) fulfilment of the 2007 European Medicine Agency algorithm for AAV, the 2022 revised Chapel Hill Consensus Conference nomenclature of vasculitides, and the 2022 American College of Rheumatology and European Alliance of Associations for Rheumatology classification criteria for MPA, GPA, and EGPA ( 2.2 Blood sampling and consent form On the day of AAV diagnosis, informed consent was obtained, AAV-specific indices were assessed, and whole blood was collected from patients with AAV

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Dexmedetomidine has been shown to decrease oxidative stress, Fe 2+ accumulation, lipid peroxidation, and restore the expression GPX4, ultimately protecting against MIRI via regulating ferroptosis (Wang et al., 2022