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Intriguingly, heparin is depicted as bound to HPX in a region overlapping with part of the site where heme binds in the crystal structure (Paoli et al., 1999) of the hemeHPX complex (Figure 8A)

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Consistently, the study by Tang et al

Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal

Overall, Piperine represents a potent, yet cautiously applicable, tool in modern drug delivery strategies