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There are significant differences in the expression and functions of HIF-1 and HIF-2 in IBD: HIF-1 exerts anti-inflammatory and protective effects by upregulating the expression of barrier-protective genes and antimicrobial peptides, whereas HIF-2 promotes epithelial cell-mediated inflammatory responses and proliferation, which are associated with chronic inflammation and carcinogenesis [33]

14 Although its exact cell of origin is still uncertain, a neural crest cell origin is possible and has been discussed, as these cells are a common precursor to both schwannomas and CNS melanocytes

10.3390/ijms18010201 Int

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