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In terms of new research avenues in the NAD + field, it is also emerging that apart from its effects on the mitochondria, NAD + plays a multitude of roles in regulating both metabolic and non-metabolic processes

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This state is mainly dominated by the infiltration and activation of immunosuppressive cells such as myeloid-derived suppressor cells, M2-type tumor-associated macrophages, and regulatory T cells [87]

Moreover, necrotic cell death in M

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