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Strict vegetarians and vegans who do not consume plant foods fortified with vitamin B12 need to consider taking a dietary supplement that contains vitamin B12 and should discuss the need for B12 supplementation with their physician

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For instance, intestinal tight junction disruption and gut epithelial barrier leakage have been considered as key pathogenic factors in IBD

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In mammals, the regulation of mitophagy appears to be more complex, both ubiquitin-mediated and receptor-mediated pathways have been described in response to mitophagy