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Since PGRMC1 dimerization involves the open surface of haem on the opposite side of the axial Tyr113, no space for CO binding is available in the dimeric structure (Fig

Therefore, it is important to develop healthy, safe and efficient natural glucokinase inhibitors

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Cell Res 17 : 195211 Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B (2007) Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response