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Following stimulation by various physiological factors (such as inflammatory triggers, vascular damage, and hemodynamic perturbations), contractile VSMCs in the normal aortic wall lose their unique structure and function, and undergo phenotypic switching to synthetic VSMCs, which is characterized by enhanced abilities of proliferation and migration, and increased secretion of various extracellular matrix proteins and cytokines (77)

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This fragmentation reflects the category's heritage in regional markets where local brands built deep consumer trust and distribution relationships before multinational competitors entered, creating resilient competitive positions despite limited resources

181 SREBP is active when sterol levels are low

Nevertheless, vitamin deficiencies lead to an increased sensitivity to pollutants and allergens and a higher susceptibility to respiratory infections, while proper vitamin levels contribute to resistance to them

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