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Ongoing study aims to develop more potent and selective STING agonists, improve delivery methods, and better understand the downstream effects of STING activation to maximize therapeutic benefits while minimizing adverse effects, and explore the effects of STING agonists in combination with other therapies (270, 271)

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Clinical activity and safety of the anti-programmed death 1 monoclonal antibody dostarlimab for patients with recurrent or advanced mismatch repair-deficient endometrial cancer: A nonrandomized phase 1 clinical trial

Autophagic flux tracing using tandem mRFP-GFP-LC3 probe showed that increase of autophagic flux caused by GSH depletion is augmented by rapamycin and attenuated by autophagic inhibitors 3-MA and Baf-A1 (Fig