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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFB signaling pathway

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Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, et al

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However, no differences between the D91A mutant and control MNs were observed, suggesting that the power of stress applied or the degree of MN maturation was insufficient for the pathological phenotype to manifest, meaning that further optimization of the study parameters is required