glutathione peroxidase 4 motor neuron Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation Small molecule selenium-based glutathione peroxidase
Small molecule selenium based glutathione peroxidase 4 mimetic inhibits lipid peroxidation and protects cultured neurons from ferroptosis ScienceDirect JCI Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide Induced Ferroptosis: Cell Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases Archives of Toxicology Springer Nature Link The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity ScienceDirect Frontiers Beyond oxidative stress: Ferroptosis as a novel orchestrator in neurodegenerative disorders
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