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The muscularis propria consists of circular smooth muscle and outer longitudinal smooth muscle bands

In hypoxia, where cellular oxygen demand exceeds supply, HIFs are stabilized and induce the transcription of HIF-target genes which promote an array of adaptive mechanisms including enhancement of anaerobic ATP generation through glycolysis [2], increased oxygen supply through angiogenesis and increased blood oxygenation through erythropoiesis [3]

Designing next-generation local drug delivery vehicles for glioblastoma adjuvant chemotherapy: lessons from the clinic

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doi: 10.1038/s41575-018-0054-1