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To determine the robustness of the screen the statistical parameter, Z-prime (Z) was determined (25) and at 40 hours of growth the values obtained were very significant (for Screen I =0.95 and for Screen II = 0.91) which suggested that the screens we developed were robust and would be compliant for a high throughput setting (Figure S6)

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Psychiatry 13 , 129 (2023)

pOPINK-Cezanne (OTU, aa 53446) was a gift from David Komander (Addgene plasmid #61581

Elkhatib et al

Third, pH-responsive porphyrin-peptide nanosheets (PRGD) encapsulating the IDO inhibitor NLG919 (PRGD/NLG919) specifically target tumor cells overexpressing v3 integrin, producing significant singlet oxygen under acidic TME conditions and eliciting strong photocytotoxicity following laser irradiation [82]