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Fourth, ROS generated by the electron leakage of the mitochondrial electron transport chain (ETC) may be another factor leading to lipid peroxidation in the process of ferroptosis in some cases ( Regulators of Iron Metabolism in Ferroptosis Although the exact mechanisms related to iron in ferroptosis remain obscure, there is no doubt about the key role of iron metabolism in the process of ferroptosis, because (1) Iron chelators block ferroptotic cell death in vitro and in vivo (Yang et al., 2016