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From a mechanistic perspective, peroxisomal -oxidation dysfunction in AP would be expected to exert a dual detrimental effect: first, by impairing the shortening of fatty acids before their transfer to mitochondria, and second, by weakening peroxisomal control of hydrogen peroxide and related redox signals

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K., Jbara A., Rabaya O., Petrova P., Daoud S., Melliti N., et al

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Paradoxically, high doses of supplemental vitamin E led exactly to the opposite effect

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Immunocytokines are a promising immunotherapeutic approach against glioblastoma

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