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Although NADPH is unable to translocate to the mitochondria across the inner membrane, its exchange between the cytosol and mitochondria is achieved by NADPH shuttle functions through the enzymes isocitrate dehydrogenase 1, [NADP +] (IDH1), and isocitrate dehydrogenase [NADP] mitochondrial (IDH2) (White et al

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50% of patients had ascites and 36% had hepatic encephalopathy

It can also interact with reduced oxygen species to form hydroxyl radical that inactivates enzymes and disrupts the membranes and organelles 44

6 Previous studies proposed the role of reactive metabolites in methimazole-induced toxicity