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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

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Overview of Acute Coronary Syndromes (ACS)