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AIM2 directly binds cytosolic dsDNA through its HIN-200 domain, independent of sequence, and assembles an inflammasome complex via its pyrin domain that recruits ASC and activates caspase-1

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The role of GRK4 in the regulation of blood pressure is confirmed in several animal models of hypertension

Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration

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Vitamin B-12 is also added to some foods, such as fortified breakfast cereals, and is available as an oral supplement