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Effect of silymarin on different acute inflammation models and on leukocyte migration

The high Th1 cytokine/cortisol/low testosterone model applies to women not men and the Enbrel/mifepristone treatment regimen is not being proposed for men

Creighton: Jaccob Daniel Clayton Bennett, sophomore, Deans List, College of Engineering, pre-engineering

Side Effects & Safety Injection site stinging/burning very common, lasting 5-15 minutes (most frequently reported side effect) Mild flushing occasional, less intense than IV route IV-specific: flushing, warmth, chest tightness, nausea common and rate-dependent, managed by slowing infusion GI discomfort with oral precursors mild and infrequent at standard doses Insomnia occasional if taken late in the day (avoid evening dosing) No serious adverse events reported in published human trials for NR 1000 mg/day or NMN 250 mg/day mg to Units Conversion On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL)

doi: 10.1016/s0021-9258(18)45278-7 83 RaeCDRowlandsBDBalcarVJ

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