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Importantly, this study differs from previous research in its experimental design

This might be responsible for the low IGF-I levels seen in association with states of insulin resistance, as the metabolic syndrome[301]

The effects of iron deficiency in tissues and reduced activity of iron-containing enzymes, such as growth retardation, abnormal behavior, and physical deficiency, can therefore be gradually corrected after active iron supplementation in iron-deficient animals, in addition to accelerating hemoglobin synthesis

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doi:10.1126/science.aax3338