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DOI:10.1111/jphp.12398 [ Links ] 41

Structure of human PRL-3, the phosphatase associated with cancer metastasis

GSEA analysis revealed a significant enrichment of a NRF2 stress-response signature 31

In a study involving 1,696 women who had experienced the loss of a family member, this stress was correlated with a 62 percent higher likelihood of contracting HPV-16 infection, along with a heightened viral load and the occurrence of repeat HPV infections

Succinate affects the stability of HIF-1 by inhibiting prolyl hydroxylase domain enzymes (PHDs), which are a class of KG-dependent dioxygenases that can regulate HIF-1 stability in an oxygen-dependent manner, preventing its degradation (117, 118)