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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

Ltd., Malvern, UK)

We now demonstrate that targeting CD38 with heavy-chain antibodies that selectively inhibit NAD glycohydrolase activity without inducing cell death or global CD38 blockade will boost tissue NAD + and precursor levels and sirtuin activity, reduce cellular senescence and mitigate fibrosis and inflammation in multiple organs

Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity

For example, guanine oxidation produces 8-oxo guanine (8-oxoG), which may lead to G-T or G-A transversions if unrepaired

In this study, we develop a model of distinct subtypes defined by the relative expression of FRGs