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When unavailable, tirzepatide + Tesamorelin offers a reasonable alternative with established safety profiles for both compounds

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Cellular stress can lead to overwhelming mitochondrial dysfunction eventually triggering its degradation by mitophagy [45, 46], and mitochondrial fission is necessary for this process [46,47,48,49]

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When data were not normally distributed the non-parametric tests such as the Mann-Whitney U-test or KruskalWallis analysis of variance were used

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