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Establishing new more holistic methods to evaluate MS treatment outcomes Biogen, along with academic partners, leveraged the AVONEX trial to introduce four clinical trial innovations that subsequently became standard practice, shaping the MS clinical development field

Chem Sci, 2022, 13: 73557364 Xu Y, Wang S, Chen Z, et al

It was shown that glutamine entry to astrocytic mitochondria is stimulated by pathopysiologically relevant concentrations of glutamine (Doliska et al., 1996)

The sgRNA targeting sequence and the following PAM sequence are highlighted in yellow and green

This binding depends on the intact N-terminal hexapeptide sequencemechanical shear stress from shaking or direct powder impact can break peptide bonds in that sequence, reducing receptor binding affinity by 1540%

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