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A trial in 38 patients treated for aggressive non-Hodgkin lymphoma evaluated the long-term efficacy and toxicity of a regimen that includes mesna, ifosfamide, mitoxantrone (Novantrone), and etoposide (known as MINE) as a post-remission treatment

This strategy, called combination chemotherapy , aims to maximize the number of cancer cells killed and minimize development of chemoresistance

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