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B-017 treatment provided significant protection of the MOM, resulting in reduced levels of inserted BAX compared to mitochondria from wild-type MEFs and MCF-7 cells treated with staurosporine alone

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The small number of patients in each cohort made it difficult to determine if this was a clinically meaningful improvement, but statistical analyses estimating the rates of BCVA change using all visits during the dosing period and the analyses estimating the change from baseline to the 24-week visit found statistically significant improvements in all cohorts, suggesting that the steady increase during the treatment period in each cohort may not be due to chance

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