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We thank the Biological Services Unit at QUB for supporting the animal studies undertaken

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Among these, BBB penetration is the most extensively studied and is considered the most promising strategy because of its minimally invasive nature (17)

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In the present study, both SOD1 and GPx expressions were significantly upregulated in the animals subjected to CSD and treated with ALA (Figure 3)

For instance, in human coronary artery endothelial cells, selective inhibition of PKC- by RBX during simulated ischemiareperfusion significantly restored Akt activation, enhanced anti-apoptotic signaling (iNOS, p-BAD), and suppressed pro-apoptotic mediators (p-FOXO, cleaved PARP, and caspase-3), thereby attenuating endothelial injury and supporting cardiovascular protection in both diabetic and non-diabetic settings [171]