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It is a novel form of iron-dependent cell death, characterized by the excessive accumulation of ROS produced by iron metabolism and lipid peroxidation products produced by lipid metabolism, as well as the abnormality of the GSH metabolic pathway caused by amino acid metabolism disorders, which is different from apoptosis, necrosis, and autophagy in morphology and biochemistry (Bruedigam et al., 2024

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Rawlings ND

[2] Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M

Its synthesis also requires several cofactors: vitamin C , vitamin B6 , niacin (B3) and iron

Chem Biol Inter 25:321344 Johnson LL, Landahl JT, Kubin LA, Horness BH, Myers MS, Collier TK, Stein JE (1998) Assessing the effects of anthropogenic stressors on Puget Sound flatfish populations