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Moreover, it negatively regulates the accessibility and infiltration of immune cells by affecting the metabolite availability for immune effector cells and by inducing an immunosuppressive phenotype via an upregulation of immune checkpoints on cancer cells, e.g., PD-L1 [11, 12]

Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand

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Maintaining a healthy weight can help reduce this risk

To test our hypothesis, we used TGF--stimulated cultured kidney tubular cells and diabetic mice models for in vitro and in vivo experiments, respectively

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