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The advantage of this type of compounds, apart from the reduction in side effects, is their efcient metabolism to non-toxic products and a high afnity for specic molecular targets, which can potentially be associated with enhanced treatment efcacy, enabling the use of a relatively low dose to produce identical biological effects [ 3 ]

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The role of Ido1 and tryptophan metabolism, together with arginine metabolizing enzymes, has been extensively studied in the context of metabolic reprogramming of immune cells for balancing immunoregulatory and pro-inflammatory phenotypes 157,158,159 , thus being critical to wound healing, neoplasia, autoimmunity and the rejection of transplanted tissues 155,160,161,162

Reinforcing previous findings 27 , our study found that L-carnitine and L-acetylcarnitine were elevated in the glaucomatous aqueous humor

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pylori mediates chronic inflammation by upregulating proinflammatory cytokines, including interleukin (IL)-8, IL-1 and tumor necrosis factor (TNF) (9-11)