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Detection and clearance of damaged lysosomes by the endo-lysosomal damage response and lysophagy

From a therapeutic standpoint, current interventions are limited

10.1016/S1875-5364(20)30051-0 50

Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Muller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J

This allows for a semiquantitative assessment of cerebral glucose metabolism which yields s Z score compared to a normal database that is part of the software program