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Advanced glycation end products, oxidation products, and the extent of atherosclerosis during the va diabetes trial and follow-up study

This can trigger heart failure by causing the retention of excess sodium and water, increasing systemic vascular resistance (the amount of force exerted on blood as it circulates through the body), and blunting the efficacy of diuretics

Nature 444 , 840846 (2006)

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Wang Z., Park K., Comer F., Hsieh-Wilson L.C., Saudek C.D., Hart G.W

Besides, these downregulated genes were mapped to several GO clusters in relation to lipid metabolism, electron transport of respiratory chain, and oxidation resistance

Clinical testing shows very minimal skin irritation and no evidence of sensitization or phototoxicity