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A photodynamic-mediated glutamine metabolic intervention nanodrug for triple negative breast cancer therapy

Interestingly, the lncRNA CCAT2 participates in the alternative splicing of glutaminase ( GLS ), an enzyme that catalyzes the hydrolysis of glutamine to glutamate (Redis et al., 2016), where glutamate can be further deaminated to a-Ketoglutarate by glutamate dehydrogenase ( GDH ) and incorporated into the tricarboxylic acid cycle (Li and Zhang, 2016)

doi: 10.1016/j.neubiorev.2007.12.001 103 HallWDLuckeJC

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In summary, PUFAs contribute to IP signaling and IPR function through multiple mechanisms: by serving as substrates for palmitoylation essential for IPR stability, by modulating membrane properties that influence receptor behavior, and by generating lipid mediators that affect downstream signaling pathways