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Gonadotropin-therapy studies (Boeri 2021) describe HCG dosing over 12-24 months, frequently combined with FSH, to induce spermatogenesis

These variations make cross-study comparisons difficult to interpret

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In preclinical models using intragastric administration, researchers observed effects comparable to parenteral routes for gastrointestinal endpoints

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In Pappa knock-out animals a 20-30% reduction in body weight was reported (31)