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In CRC, SHMT2 has been shown to bind competitively to the cytosolic p53 protein, thereby sequestering the E3 ubiquitin ligase HDM2(Human double minute 2), thereby inhibiting autophagy and conferring resistance to 5-fluorouracil (5-FU) chemotherapy [104]

Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet

It comprises several interdependent components that work in concert to maintain GI homeostasis and immune surveillance (Figure 1)

These systems are unique in that they have a hydrophobic core that functions as an efficient carrier for the delivery of hydrophobic drugs, Paclitaxel [53], Budesonide [95], and Celecoxib [96], and a very hydrophilic polysaccharide backbone that serves as a shell for such poorly water-soluble pharmaceuticals

rather, MAPKs appear to regulate the NRF2 signalling pathway mainly through indirect mechanisms [210]

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