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Similarly, GSH-conjugation/detoxification (including ROS) activity by GST, which also has GSH-peroxidase activity, is increased by ASA in GSH-depleted cells

On the other hand, in the pathway that is not dependent on MyD88, TLR is responsible for recruiting adaptor proteins such as translocating chain-associated membrane protein (TRAM) and TIR-domain-containing adaptor-inducing interferon (TRIF)

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75 Notably, a previous study found that damaged LSECs could result in liver congestion, and APAP might be directly toxic to the LSECs isolated from mice through the depletion of GSH