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Studies indicate that HIF-2, upon stimulation by inflammatory factors such as IL-1, leads to a decrease in GSH levels, thereby increasing chondrocytes sensitivity to lipid peroxidation and ferroptosis

J Gerontol A Biol Sci Med Sci , 1997

The mutant achieved 3.1-fold higher ATP-generating activity and 1.7-fold higher GSH productivity compared with the control strain

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