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ROS are capable of oxidizing proteins, pigments, lipids, nucleic acids, and other cell molecules, disrupting their functional activity

& Kruger, H

The hydrophobicity of the phenylalanine cluster in crevasse, along with the ability of fatty acids longer than octanoic acid (C8:0), such as lauric acid (C12:0) and palmitic acid (C16:0), to activate the ghrelin receptor, initially led to the hypothesis that the fatty acid chain of ghrelin extends through this crevasse into the cell membrane (Matsumoto et al., 2001)

For its development, BioNTech collaborated with the American company Pfizer to carry out clinical trials, logistics, and manufacturing

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This activation leads to the phosphorylation and activation of STAT proteins, which in turn promotes the expression of inflammation-related genes