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Additional supplementation with other mitochondrial support nutrients nicotinamide adenine dinucleotide (NADH), acetyl-L-carnitine, and phosphatidylserine (PS) could diversify energy input to the mitochondria and further help compensate for the energetic impairment of PD

459 Antimicrobial drugs inhibit microbial growth by increasing intracellular copper ion concentrations and can also function as copper ionophores to suppress cancer

Protein-based sensors have proven successful to monitor metabolites such as H 2 O 2 or calcium in live cells and organisms 11,12

Increasing Fpn levels were linked to reduced Mn accumulation in both the cerebellum and cortex of mice treated with Mn (Yin et al., 2010), further confirming that Fpn removes Mn and reduces Mn-induced neurotoxicity

If the compound binds to the receptor, the binding of labeled ligand to the receptor is inhibited as determined by a reduction of labeled ligand which binds to the receptors

Inhibition of TrxR by auranofin can lead to elevated ROS and RNS levels, apoptosis, and decreased cell proliferation