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albicans is a constituent of oral plaque, this is consistent with clinical data (Fig

Moreover, L.reuteri 5289 inhibited the generation of DCs and associated production of IL-12, whereas induced the expression of IL-10, which is associated with prolonged phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) in the MAPK pathway ( Figure 2G )

10.1055/s-2008-1066181 10

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a Hersbach, H., Bell, B., Berrisford, P., Biavati, G., Hornyi, A., Muoz Sabater, J., Nicolas, J., Peubey, C., Radu, R., Rozum, I., Schepers, D., Simmons, A., Soci, C., Dee, D., and Thpaut, J.-N.: ERA5 hourly data on single levels from 1940 to present, Climate Data Store [data set], 2023b

The mechanisms are multiple and interconnected rather than reducing to a single receptor or pathway, reflecting the broad biological footprint of copper-dependent biology