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Riboflavin has therapeutic potential for certain mitochondrial disorders, such as mutations in the X-linked apoptosis-inducing factor mitochondria-associated 1 (AIFM1) and mitochondrial complex I deficiency nuclear type 20 or mitochondrial complex II deficiency (, )

Burgdorf, J

Oxidative metabolism signatures predict response to 5FU-based chemotherapy treatment Given this robust adaptation to facilitate cellular survival in cancer cells treated with 5FU, we next postulated that elevated mitochondrial metabolism may be a predictor of response to 5FU-based chemotherapy

reported that MTX caused weight loss due to malabsorption and enterocolitis in rats (Reference Fox, Kripke and De Paula37,Reference Jahovic, Cevik and Sehirli38)

Another inhibitor VPS34, which blocks autophagosome production, also abolished the effect of MoeA on bacterial survival in host cells (Fig